Do we really need high-sensitive troponin immunoassays in the emergency department? Definitely, yes!

被引:6
作者
Lackner, Karl J. [1 ]
机构
[1] Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, D-55131 Mainz, Germany
关键词
cardiac troponins; high sensitivity; myocardial infarction; ACUTE MYOCARDIAL-INFARCTION; EARLY-DIAGNOSIS; SERIAL CHANGES; I ASSAY; PERFORMANCE;
D O I
10.1515/cclm-2013-0604
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Cardiac troponins have changed our understanding of myocardial infarction profoundly during the past 20 years. In fact release of cardiac troponin into the blood has become part of the definition of myocardial infarction. Diagnostics and treatment have taken these new insights into account. The novel high-sensitive assays for cardiac troponins that are available recently clearly constitute a significant further improvement of analytical performance. In addition, the still incomplete clinical data available indicate that these assays will also further improve patient care in many ways. In summary, cardiac troponins are a great example of the potential impact of analytical performance of diagnostic tests on patient care and patient outcome.
引用
收藏
页码:201 / 204
页数:4
相关论文
共 11 条
[1]   Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays [J].
Apple, Fred S. ;
Collinson, Paul O. .
CLINICAL CHEMISTRY, 2012, 58 (01) :54-61
[2]   High-Sensitivity Cardiac Troponin T for Early Prediction of Evolving Non-ST-Segment Elevation Myocardial Infarction in Patients with Suspected Acute Coronary Syndrome and Negative Troponin Results on Admission [J].
Giannitsis, Evangelos ;
Becker, Meike ;
Kurz, Kerstin ;
Hess, Georg ;
Zdunek, Dietmar ;
Katus, Hugo A. .
CLINICAL CHEMISTRY, 2010, 56 (04) :642-650
[3]   ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J].
Hamm, Christian W. ;
Bassand, Jean-Pierre ;
Agewall, Stefan ;
Bax, Jeroen ;
Boersma, Eric ;
Bueno, Hector ;
Caso, Pio ;
Dudek, Dariusz ;
Gielen, Stephan ;
Huber, Kurt ;
Ohman, Magnus ;
Petrie, Mark C. ;
Sonntag, Frank ;
Uva, Miguel Sousa ;
Storey, Robert F. ;
Wijns, William ;
Zahger, Doron .
EUROPEAN HEART JOURNAL, 2011, 32 (23) :2999-3054
[4]   Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction [J].
Keller, Till ;
Zeller, Tanja ;
Ojeda, Francisco ;
Tzikas, Stergios ;
Lillpopp, Lars ;
Sinning, Christoph ;
Wild, Philipp ;
Genth-Zotz, Sabine ;
Warnholtz, Ascan ;
Giannitsis, Evangelos ;
Moeckel, Martin ;
Bickel, Christoph ;
Peetz, Dirk ;
Lackner, Karl ;
Baldus, Stephan ;
Muenzel, Thomas ;
Blankenberg, Stefan .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (24) :2684-2693
[5]   Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction. [J].
Keller, Till ;
Zeller, Tanja ;
Peetz, Dirk ;
Tzikas, Stergios ;
Roth, Alexander ;
Czyz, Ewa ;
Bickel, Christoph ;
Baldus, Stephan ;
Warnholtz, Ascan ;
Froehlich, Meike ;
Sinning, Christoph R. ;
Eleftheriadis, Medea S. ;
Wild, Philipp S. ;
Schnabel, Renate B. ;
Lubos, Edith ;
Jachmann, Nicole ;
Genth-Zotz, Sabine ;
Post, Felix ;
Nicaud, Viviane ;
Tiret, Laurence ;
Lackner, Karl J. ;
Muenzel, Thomas ;
Blankenberg, Stefan .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (09) :868-877
[6]   Laboratory diagnostics of myocardial infarction - troponins and beyond [J].
Lackner, Karl J. .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2013, 51 (01) :83-89
[7]   Risk stratification in patients with unstable angina using absolute serial changes of 3 high-sensitive troponin assays [J].
Reichlin, Tobias ;
Twerenbold, Raphael ;
Maushart, Claudia ;
Reiter, Miriam ;
Moehring, Berit ;
Schaub, Nora ;
Balmelli, Cathrin ;
Gimenez, Maria Rubini ;
Hoeller, Rebeca ;
Sakarikos, Konstantin ;
Drexler, Beatrice ;
Haaf, Philip ;
Osswald, Stefan ;
Mueller, Christian .
AMERICAN HEART JOURNAL, 2013, 165 (03) :371-+
[8]   One-Hour Rule-out and Rule-in of Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin T [J].
Reichlin, Tobias ;
Schindler, Christian ;
Drexler, Beatrice ;
Twerenbold, Raphael ;
Reiter, Miriam ;
Zellweger, Christa ;
Moehring, Berit ;
Ziller, Ronny ;
Hoeller, Rebeca ;
Gimenez, Maria Rubini ;
Haaf, Philip ;
Potocki, Mihael ;
Wildi, Karin ;
Balmelli, Cathrin ;
Freese, Michael ;
Stelzig, Claudia ;
Freidank, Heike ;
Osswald, Stefan ;
Mueller, Christian .
ARCHIVES OF INTERNAL MEDICINE, 2012, 172 (16) :1211-1218
[9]   Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays. [J].
Reichlin, Tobias ;
Hochholzer, Willibald ;
Bassetti, Stefano ;
Steuer, Stephan ;
Stelzig, Claudia ;
Hartwiger, Sabine ;
Biedert, Stefan ;
Schaub, Nora ;
Buerge, Christine ;
Potocki, Mihael ;
Noveanu, Markus ;
Breidthardt, Tobias ;
Twerenbold, Raphael ;
Winkler, Katrin ;
Bingisser, Roland ;
Mueller, Christian .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (09) :858-867
[10]  
Spencer CA, 1996, CLIN CHEM, V42, P140