Why Primate Models Matter

被引：452

作者：

Phillips, Kimberley A. ^{[1
,2
]}

Bales, Karen L. ^{[3
,4
]}

Capitanio, John P. ^{[3
,4
]}

Conley, Alan ^{[5
]}

Czoty, Paul W. ^{[6
]}

't Hart, Bert A. ^{[7
]}

Hopkins, William D. ^{[8
,9
,10
]}

Hu, Shiu-Lok ^{[11
,12
]}

Miller, Lisa A. ^{[4
,13
]}

Nader, Michael A. ^{[6
]}

Nathanielsz, Peter W. ^{[14
]}

Rogers, Jeffrey ^{[15
,16
]}

Shively, Carol A. ^{[17
]}

Voytko, Mary Lou ^{[18
]}

机构：

[1] Trinity Univ, Dept Psychol, San Antonio, TX 78212 USA

[2] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA

[3] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[4] Calif Natl Primate Res Ctr, Davis, CA USA

[5] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA

[6] Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA

[7] Biomed Primate Res Ctr, Dept Immunobiol, Rijswick, Netherlands

[8] Georgia State Univ, Inst Neurosci, Atlanta, GA 30303 USA

[9] Georgia State Univ, Language Res Ctr, Atlanta, GA 30303 USA

[10] Yerkes Natl Primate Res Ctr, Div Cognit & Dev Neurosci, Atlanta, GA USA

[11] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA

[12] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA

[13] Univ Calif Davis, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA

[14] Univ Texas Hlth Sci Ctr San Antonio, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA

[15] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[16] Wisconsin Natl Primate Res Ctr, Madison, WI USA

[17] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med Sect, Winston Salem, NC 27103 USA

[18] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Winston Salem, NC USA

来源：

AMERICAN JOURNAL OF PRIMATOLOGY | 2014年 / 76卷 / 09期

关键词：

animal models; translational research; nonhuman primates; CORONARY-HEART-DISEASE; HIGH-FAT DIET; IMMUNODEFICIENCY VIRUS-INFECTION; PROSTATE-SPECIFIC ANTIGEN; PERIPHERAL PLASMA-LEVELS; GENE-EXPRESSION PROFILE; ESTROGEN PLUS PROGESTIN; HIGHLY PATHOGENIC SIV; T-CELL DEPLETION; NONHUMAN-PRIMATE;

D O I：

10.1002/ajp.22281

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research. (C) 2014 Wiley Periodicals, Inc.

引用

页码：801 / 827

页数：27

共 367 条

[1] Nonhuman primate models of polycystic ovary syndrome [J].

Abbott, David H. ;

Nicol, Lindsey E. ;

Levine, Jon E. ;

Xu, Ning ;

Goodarzi, Mark O. ;

Dumesic, Daniel A. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2013, 373 (1-2) :21-28

[2]

Abbott David H., 2008, V13, P145, DOI 10.1159/000134831

[3] Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women [J].

Karim, Quarraisha Abdool ;

Karim, Salim S. Abdool ;

Frohlich, Janet A. ;

Grobler, Anneke C. ;

Baxter, Cheryl ;

Mansoor, Leila E. ;

Kharsany, Ayesha B. M. ;

Sibeko, Sengeziwe ;

Mlisana, Koleka P. ;

Omar, Zaheen ;

Gengiah, Tanuja N. ;

Maarschalk, Silvia ;

Arulappan, Natasha ;

Mlotshwa, Mukelisiwe ;

Morris, Lynn ;

Taylor, Douglas .

SCIENCE, 2010, 329 (5996) :1168-1174

[4] OVARIECTOMY, SOCIAL-STATUS, AND ATHEROSCLEROSIS IN CYNOMOLGUS MONKEYS [J].

ADAMS, MR ;

KAPLAN, JR ;

CLARKSON, TB ;

KORITNIK, DR .

ARTERIOSCLEROSIS, 1985, 5 (02) :192-200

[5] INHIBITION OF CORONARY-ARTERY ATHEROSCLEROSIS BY 17-BETA ESTRADIOL IN OVARIECTOMIZED MONKEYS - LACK OF AN EFFECT OF ADDED PROGESTERONE [J].

ADAMS, MR ;

KAPLAN, JR ;

MANUCK, SB ;

KORITNIK, DR ;

PARKS, JS ;

WOLFE, MS ;

CLARKSON, TB .

ARTERIOSCLEROSIS, 1990, 10 (06) :1051-1057

[6] A systematic review on animal models of maternal high fat feeding and offspring glycaemic control [J].

Ainge, H. ;

Thompson, C. ;

Ozanne, S. E. ;

Rooney, K. B. .

INTERNATIONAL JOURNAL OF OBESITY, 2011, 35 (03) :325-335

[7] PLACENTAL STEROID-HORMONE BIOSYNTHESIS IN PRIMATE PREGNANCY [J].

ALBRECHT, ED ;

PEPE, GJ .

ENDOCRINE REVIEWS, 1990, 11 (01) :124-150

[8] Equine placentation [J].

Allen, WR ;

Stewart, F .

REPRODUCTION FERTILITY AND DEVELOPMENT, 2001, 13 (7-8) :623-634

[9] The von Economo neurons in the frontoinsular and anterior cingulate cortex [J].

Allman, John M. ;

Tetreault, Nicole A. ;

Hakeem, Atiya Y. ;

Manaye, Kebreten F. ;

Semendeferi, Katerina ;

Erwin, Joseph M. ;

Park, Soyoung ;

Goubert, Virginie ;

Hof, Patrick R. .

NEW PERSPECTIVES ON NEUROBEHAVIORAL EVOLUTION, 2011, 1225 :59-71

[10] TRANSMISSION OF HTLV-III INFECTION FROM HUMAN-PLASMA TO CHIMPANZEES - AN ANIMAL-MODEL FOR AIDS [J].

ALTER, HJ ;

EICHBERG, JW ;

MASUR, H ;

SAXINGER, WC ;

GALLO, R ;

MACHER, AM ;

LANE, HC ;

FAUCI, AS .

SCIENCE, 1984, 226 (4674) :549-552

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