The role of necrotic cell death in the pathogenesis of immune mediated nephropathies

被引：16

作者：

Jog, Neelakshi R. ^{[1
]}

Caricchio, Roberto ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Med, Rheumatol Sect,Temple Autoimmun Ctr, Philadelphia, PA 19140 USA

来源：

CLINICAL IMMUNOLOGY | 2014年 / 153卷 / 02期

关键词：

Nephritis; Autoimmunity; Cell death; Necrosis; TUMOR-NECROSIS-FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHURG-STRAUSS-SYNDROME; EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS; MITOCHONDRIAL PERMEABILITY TRANSITION; BASEMENT-MEMBRANE GLOMERULONEPHRITIS; ANCA-ASSOCIATED GLOMERULONEPHRITIS; NEUTROPHIL EXTRACELLULAR TRAPS; GLOMERULAR MESANGIAL CELLS; HENOCH-SCHONLEIN PURPURA;

D O I：

10.1016/j.clim.2014.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Necrosis, an inflammatory form of cell death, has been considered to be an accidental death and/or cell death due to injury. However, the literature in the last decade has established that necrosis is a regulated form of cell death, and that inhibition of specific molecular pathways leading to necrosis can block it and reduce inflammation. Since necrotic lesions are observed in several immune mediated human pathologies, in this review we will discuss the impact that this form of programmed cellular demise has in the pathology of immune mediated nephropathies. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：243 / 253

页数：11

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