Biological applications of LbL multilayer capsules: From drug delivery to sensing

被引：114

作者：

del Mercato, Loretta Laureana ^{[1
]}

Ferraro, Marzia Maria ^{[1
]}

Baldassarre, Francesca ^{[1
]}

Mancarella, Serena ^{[1
]}

Greco, Valentina ^{[1
]}

Rinaldi, Ross ^{[1
,2
]}

Leporatti, Stefano ^{[1
]}

机构：

[1] CNR, NNL Ist Nanosci, Lecce, Italy

[2] Univ Salento, Dipartimento Matemat & Fis Ennio De Giorgi, Lecce, Italy

来源：

ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2014年 / 207卷

关键词：

Layer-by-Layer; Polymer capsules; Drug delivery; Cancer therapy; Biosensing; Optical reporters; HOLLOW POLYELECTROLYTE MICROCAPSULES; GALACTOSE-BRANCHED POLYELECTROLYTE; FLUORESCENT SENSORS; POLYMER MICROCAPSULES; SUSTAINED-RELEASE; ULTRATHIN FILMS; CLICK CHEMISTRY; GROWTH-FACTOR; CANCER-CELLS; PH;

D O I：

10.1016/j.cis.2014.02.014

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polyelectrolyte multilayer (PEM) capsules engineered with active elements for targeting, labeling, sensing and delivery hold great promise for the controlled delivery of drugs and the development of new sensing platforms. PEM capsules composed of biodegradable polyelectrolytes are fabricated for intracellular delivery of encapsulated cargo (for example peptides, enzymes, DNA, and drugs) through gradual biodegradation of the shell components. PEM capsules with shells responsive to environmental or physical stimuli are exploited to control drug release. In the presence of appropriate triggers (e.g., pH variation or light irradiation) the pores of the multilayer shell are unlocked, leading to the controlled release of encapsulated cargos. By loading sensing elements in the capsules interior, PEM capsules sensitive to biological analytes, such as ions and metabolites, are assembled and used to detect analyte concentration changes in the surrounding environment. This Review aims to evaluate the current state of PEM capsules for drug delivery and sensing applications. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：139 / 154

页数：16

共 154 条

[1] How Colloidal Nanoparticles Could Facilitate Multiplexed Measurements of Different Analytes with Analyte-Sensitive Organic Fluorophores [J].