Synthesis and antimicrobial activity of 1H,10H-benzo[e]pyrrolo[3,2-g]indole derivatives

被引：13

作者：

Samsoniya, Sh. A. ^{[1
]}

Trapaidze, M. V. ^{[1
]}

Kuprashvili, N. A. ^{[1
]}

机构：

[1] Ivane Javakhishvili Tbilisi State Univ, Tbilisi, Georgia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 02期

基金：

美国国家科学基金会;

关键词：

benzopyrroloindole; phenylazoderivatives; azocoupling; antimicrobial; antifungal; antituberculosis activity; PYRROLOINDOLES;

D O I：

10.1007/s11094-009-0245-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a series of new phenylazo derivatives of 1H,10H-benzo[e]pyrrolo[3, 2-g]indole containing 3-(p-bromophenylazo) (II), 3-(p-iodophenylazo) (III), 3-(p-sulfamidophenylazo) (IV), 3-formyl (V), 3,8-diformyl (VI), 3-phenylazo (VII), 3-(p-chlorophenylazo) (VIII), 3-(p-nitrophenylazo) (IX), 2,9-di(adamantylaminocarbonyl) (X), 2,9-di(p-benzenesulfamidoaminocarbonyl) (XI), 2,9-di(isonicotinoylhydrazidecarbonyl) (XII), and 2,9-di(carbohydrazide) (XIII) substituents. The antimicrobial, antifungal, and antituberculosis activity was investigated in vitro with respect to various microorganisms including conditionally pathogenic mycobacteria and pathogenic fungi. It is established that the tested compounds possess high antimicrobial activity. The synthesized compounds are of great interest for further, more thorough investigations and experiments on animals with the corresponding infectious diseases.

引用

页码：92 / 94

页数：3