β-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation

被引：66

作者：

Diergaarde, L ^{[1
]}

Schoffelmeer, ANM ^{[1
]}

De Vries, TJ ^{[1
]}

机构：

[1] Free Univ Amsterdam, Neurosci Res Inst,Med Ctr, Ctr Neurogenom & Cognit Res, Dept Anat & Neurosci, NL-1081 BT Amsterdam, Netherlands

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 170卷 / 02期

关键词：

memory reconsolidation; instrumental learning; sucrose;

D O I：

10.1016/j.bbr.2006.02.014

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：333 / 336

页数：4

共 21 条

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