β-adrenoceptor mediated inhibition of long-term reward-related memory reconsolidation

被引:66
|
作者
Diergaarde, L [1 ]
Schoffelmeer, ANM [1 ]
De Vries, TJ [1 ]
机构
[1] Free Univ Amsterdam, Neurosci Res Inst,Med Ctr, Ctr Neurogenom & Cognit Res, Dept Anat & Neurosci, NL-1081 BT Amsterdam, Netherlands
关键词
memory reconsolidation; instrumental learning; sucrose;
D O I
10.1016/j.bbr.2006.02.014
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:333 / 336
页数:4
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