Cancer-Cell-Targeted Theranostic Cubosomes

被引：88

作者：

Caltagirone, Claudia ^{[1
]}

Falchi, Angela Maria ^{[2
]}

Lampis, Sandrina ^{[1
]}

Lippolis, Vito ^{[1
]}

Meli, Valeria ^{[1
]}

Monduzzi, Maura ^{[1
]}

Prodi, Luca ^{[3
]}

Schmidt, Judith ^{[4
]}

Sgarzi, Massimo ^{[3
]}

Talmon, Yeshayahu ^{[4
]}

Bizzarri, Ranieri ^{[5
]}

Murgia, Sergio ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Sci Chim & Geol, I-09042 Monserrato, CA, Italy

[2] Univ Cagliari, Dipartimento Sci Biomed, I-09042 Monserrato, CA, Italy

[3] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[4] Technion Israel Inst Technol, Dept Chem Engn, IL-32000 Haifa, Israel

[5] UO Pisa, CNR, Ist Biofis, I-56124 Pisa, Italy

来源：

LANGMUIR | 2014年 / 30卷 / 21期

关键词：

NEAR-INFRARED FLUORESCENT; MRI CONTRAST AGENTS; ANTICANCER DRUG; RECENT PROGRESS; QUANTUM DOTS; IN-VIVO; NANOPARTICLES; DELIVERY; THERAPY; CAMPTOTHECIN;

D O I：

10.1021/la501332u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work was devoted to the development of a new type of lipid-based (cubosome) theranostic nanoparticle able to simultaneously host camptothecin, a potent anticancer drug, and a squarain-based NIR-emitting fluorescent probe. Furthermore, to confer targeting abilities on these nanoparticles, they were dispersed using mixtures of Pluronic F108 and folate-conjugated Pluronic F108 in appropriate ratios. The physicochemical characterization, performed via SAXS, DLS, and cryo-TEM techniques, proved that aqueous dispersions of such cubosomes can be effectively prepared, while the photophysical characterization demonstrated that these nanoparticles may be used for in vivo imaging purposes. The superior ability of these innovative nanoparticles in targeting cancer cells was emphasized by investigating the lipid droplet alterations induced in He La cells upon exposure to targeted and nontargeted cubosomes.

引用

页码：6228 / 6236

页数：9

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