Value of Two-Dimensional Longitudinal Strains Analysis to Assess the Impact of Thrombus Aspiration during Primary Percutaneous Coronary Intervention on Left Ventricular Function: A Speckle Tracking Imaging Substudy of the EXPIRA Trial

BackgroundThrombectomy during primary percutaneous coronary intervention (Th-PCI) improves myocardial reperfusion in the absence of significant changes, in the acute phase, in traditional two-dimensional (2D) echo indexes of left ventricular (LV) function. The aim of this study was to evaluate the potential of 2D speckle tracking echocardiography (2DSTE) analysis in assessing the efficacy of thrombectomy as compared to standard 2D echo and cardiac magnetic resonance (CMR) data. MethodsTwo-dimensional speckle tracking echocardiography analysis was performed in 60 anterior ST-segment elevation myocardial infarction (STEMI) patients to assess global (GLS), segmental (SLS) and regional longitudinal strain (RLS). 2D echo and CMR were performed within 5days after PCI. Patients were divided into 2 groups according to the different methods of reperfusion used: 28 pts Th-PCI and 32 pts standard PCI (S-PCI). ResultsBaseline clinical and angiographic characteristics, 2D echo, and DE-CMR data before and after PCI were similar in the 2 groups, except for microvascular obstruction (MVO), significantly lower (P=0.001) in Th-PCI group. Conversely, GLS was significantly higher in Th-PCI group (P<0.001), and in particular in the subset of patients without MVO (P=0.012). RLS was also significantly higher in Th-PCI group (P=0.001). GLS significantly correlates with infarct size, (R=0.47; P=0.03) and MVO (R=0.69, P=0.001). Finally, SLS was significantly lower in the DE segments (P<0.001). ConclusionsPatients treated with Th-PCI had a more preserved microvascular integrity resulting in a better myocardial longitudinal deformation. 2DSTE analysis adds significant information on the efficacy of thrombus aspiration as compared to standard echocardiography and it is closely related to the extent of microvascular damage.