Dynamic kinetic resolution of atropisomeric amides

被引：70

作者：

Chan, V ^{[1
]}

Kim, JG ^{[1
]}

Jimeno, C ^{[1
]}

Carroll, PJ ^{[1
]}

Walsh, PJ ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, P Roy & Diana T Vagelos Labs, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol0492952

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using L-proline as catalyst in the asymmetric aldol reaction and a series of benzamides and naphthamides, we have accomplished a dynamic kinetic resolution that simultaneously establishes the stereochemistry of the atropisomeric amide's chiral axis and a stereogenic center. The enantioselectivities ranged from 82% to 95% and the diastereoselectivities from 2.1:1 to 7.01.

引用

页码：2051 / 2053

页数：3

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