Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

被引：44
|
作者：
Liu, SH [1 ]
Hamilton, AD [1 ]
机构：
[1] UNIV PITTSBURGH, DEPT CHEM, PITTSBURGH, PA 15260 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0960-894X(97)00303-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysts for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1779 / 1784
页数：6
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