Type 2 Diabetes Mellitus and Vertebral Fracture Risk

被引：38

作者：

Koromani, Fjorda ^{[1
,2
]}

Ghatan, Samuel ^{[1
,3
]}

van Hoek, Mandy ^{[1
]}

Zillikens, M. Carola ^{[1
]}

Oei, Edwin H. G. ^{[2
]}

Rivadeneira, Fernando ^{[1
,3
]}

Oei, Ling ^{[1
,3
,4
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Internal Med, POB 2040 Na27-24, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[4] Leiden Univ, Med Ctr, Dept Internal Med, Leiden, Netherlands

来源：

CURRENT OSTEOPOROSIS REPORTS | 2021年 / 19卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

Vertebral fractures; Diabetes; Osteoporosis; BMD; TBS; TRABECULAR BONE SCORE; ALL-CAUSE MORTALITY; MINERAL DENSITY; POSTMENOPAUSAL WOMEN; OSTEOPOROTIC FRACTURES; ASSESSMENT TOOL; ELDERLY-MEN; METAANALYSIS; PREVALENCE; TBS;

D O I：

10.1007/s11914-020-00646-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.

引用

页码：50 / 57

页数：8

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