Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum

被引：15
|
作者：
Ismail, Intan Safinar [1 ,2 ]
Nagakura, Yuta [1 ]
Hirasawa, Yusuke [1 ]
Hosoya, Takahiro [1 ]
Lazim, Mohd Izwan Mohd [2 ]
Lajis, Nordin Hj [2 ]
Morita, Hiroshi [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
[2] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang, Malaysia
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 34期
关键词：
LIMONOIDS; MELIACEAE; HAINANENSE; PLANTS;
D O I：
10.1016/j.tetlet.2009.05.110
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel triterpenes, acutaxylines A (1) and B (2) consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol, were isolated from the leaves of Dysoxylum acutangulum. The relative stereochemistry of 1 and 2 was determined by NOESY correlations. Acutaxyline B showed moderate cytotoxicity against human blood premyelocytic leukemia cells. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4830 / 4832
页数：3
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