Electrochemical Oxidative Cyclization: Synthesis of Polysubstituted Pyrrole from Enamines

被引：17

作者：

Chen, Zhiwei ^{[1
]}

Shi, Guang ^{[1
]}

Tang, Wei ^{[1
]}

Sun, Jie ^{[1
]}

Wang, Wenxing ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 06期

关键词：

Electrochemical reactions; Enamines; Polysubstituted pyrrole; Cross-coupling; Oxidative annulation; C-H FUNCTIONALIZATION; HYDROGENATION; ACTIVATION; ANNULATION; ALKYNES; DESIGN; ESTERS;

D O I：

10.1002/ejoc.202001484

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A conceptually novel method for the preparation of pyrrole is described by electrochemical-oxidation-induced intermolecular annulation via enamines. In a simple undivided cell, based on a sodium acetate-facilitated, polysubstituted pyrrole derivations has been facilely synthesized under external oxidant-free condition. This electrosynthetic approach providing an environmentally benign protocol for C-C bond cross-coupling and oxidative annulation, which features unparalleled broad scope of substrates and practicality.

引用

页码：951 / 955

页数：5

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