N-Bromosuccinimide Promoted Direct Thiolation of Imidazoheteroaryl C-H bonds with Disulfides

被引：19
|
作者：
Maddi, Raghavender Reddy [1 ]
Shirsat, Prashishkumar K. [1 ]
Kumar, Santosh [1 ]
Meshram, H. M. [1 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad, Andhra Pradesh, India
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 04期
关键词：
Disulfides; Imidazopyridines; Low temperature reaction; N-Bromosuccinimide; Sulfenylation; ANTIVIRAL ACTIVITY; DERIVATIVES; HETEROCYCLES; CYCLIZATION; ACTIVATION; INHIBITORS; ACCESS;
D O I：
10.1002/slct.201601460
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one-pot protocol has been demonstrated for the regioselective sulfenylation of imidazoheterocycles with disulfides. In this method, thiols are converted to sulfenyl bromides and reacted with 2-phenylimidazo [1, 2-a] pyridines. This simple procedure is highly capable for sulfenylation with readily available starting materials in good to excellent yields under transition metal and base free conditions.
引用
收藏
页码：1544 / 1547
页数：4
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