Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications

被引：20

作者：

Ao, Zheng ^{[1
]}

Parasido, Erika ^{[2
,3
]}

Rawal, Siddarth ^{[1
]}

Williams, Anthony ^{[1
]}

Schlegel, Richard ^{[2
,3
]}

Liu, Stephen ^{[2
,3
]}

Albanese, Chris ^{[2
,3
]}

Cote, Richard J. ^{[1
]}

Agarwal, Ashutosh ^{[1
,4
]}

Datar, Ram H. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA

[2] Georgetown Univ, Med Ctr, Dept Pathol & Oncol, Washington, DC 20057 USA

[3] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA

[4] Univ Miami, Dept Biomed Engn, Coral Gables, FL 33124 USA

来源：

LAB ON A CHIP | 2015年 / 15卷 / 22期

关键词：

METASTATIC BREAST-CANCER; EPITHELIAL-CELLS; ROCK INHIBITOR; PARYLENE-C; CHIP; SURFACES; SURVIVAL; CAPTURE; SINGLE; BLOOD;

D O I：

10.1039/c5lc01024a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses. Here, we present a temperature responsive polymer coating method to achieve both release as well as culture of viable CTCs captured from patient blood samples.

引用

页码：4277 / 4282

页数：6

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