DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins

被引：25
|
作者：
Wlazlo, AP [1 ]
Deng, HY [1 ]
Giles-Davis, W [1 ]
Ertl, HCJ [1 ]
机构：
[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
来源：
CANCER GENE THERAPY | 2004年 / 11卷 / 06期
基金：
美国国家卫生研究院;
关键词：
DNA; vaccine; papillomavirus; cancer; E6; E7;
D O I：
10.1038/sj.cgt.7700723
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
DNA vaccines expressing the E6 or E7 oncoproteins of human papilloma virus type 16 (HPV-16) in either their wild-type form or fused to sequences that affect intracellular trafficking were tested for induction of protective immunity against tumor cell challenge in two models based on BALB/c and C57Bl/6 mice. The DNA vaccines to E7 gave uniformly disappointing results, while the DNA vaccine that expressed E6 linked to a viral leader sequence protected BALB/c mice against tumor cell challenge given before or after vaccination. The efficacy of this vaccine could be enhanced by a DNA vector prime/viral vector boost regimen. In contrast, priming of mice with the DNA vaccines to E7 reduced the efficacy of a viral vector expressing the same antigen.
引用
收藏
页码：457 / 464
页数：8
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