A New Isochroman Derivative from the Marine Fungus Phomopsis sp (No. Gx-4)

被引：10

作者：

Yang, Jian Xiang ^{[1
,3
]}

Qiu, ShengXiang ^{[1
]}

She, Zhigang ^{[2
]}

Lin, Yongcheng ^{[2
]}

机构：

[1] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[3] Guilin Normal Coll, Dept Chem & Engn, Guilin 541002, Guangxi, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 03期

基金：

中国国家自然科学基金;

关键词：

natural product; isochroman derivative; marine fungus; bioassays; NMR assignment; CHINA SEA COAST; MANGROVE FUNGUS; METABOLITES;

D O I：

10.1007/s10600-014-0976-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new isochroman, (3R,4S)-3,4-dihydro-8-hydroxy-4-methoxy-3-methylisocoumarin (1), and three known compounds were isolated from the marine fungus Phomopsis sp. (No. Gx-4). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR. Primary bioassays and preliminary pharmacological tests revealed that compounds 1 and 3 can accelerate the growth of subintestinal vessel plexus (SIV) branches markedly, but compounds 2 and 4 can inhibit their growth.

引用

页码：424 / 426

页数：3

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