Bafilomycin A(1) induces apoptosis in PC12 cells independently of intracellular pH

被引：31
|
作者：
Kinoshita, K [1 ]
Waritani, T [1 ]
Noto, M [1 ]
Takizawa, K [1 ]
Minemoto, Y [1 ]
Nishikawa, Y [1 ]
Ohkuma, S [1 ]
机构：
[1] KANAZAWA UNIV, FAC PHARMACEUT SCI, DEPT BIOCHEM, KANAZAWA, ISHIKAWA 920, JAPAN
来源：
FEBS LETTERS | 1996年 / 398卷 / 01期
关键词：
bafilomycin A(1); apoptosis; vacuolar H+-ATPase; NH4Cl; PC12; cell;
D O I：
10.1016/S0014-5793(96)01182-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PC12 cells growth-arrested with bafilomycin A(1) died showing apoptotic chromatin condensation in the nuclei. The bafilomycin A(1)-induced chromatin condensation was preceded by neurite outgrowth (NOG), required higher concentrations of bafilomycin A(1) than NOG, and was suppressed by cycloheximide and aurintricarboxylic acid. NH4Cl (10 mM), another acidotropic pH perturbing agent, neither induced apoptotic chromatin condensation by itself nor suppressed that induced by bafilomycin A(1), suggesting that bafilomycin A(1)-induced apoptosis occurs independently of intracellular pH in PC12 cells.
引用
收藏
页码：61 / 66
页数：6
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