Role of the Sonic Hedgehog pathway in thoracic cancers

被引：4

作者：

Leprieur, E. Giroux ^{[1
,2
]}

Antoine, M. ^{[1
]}

Vieira, T. ^{[1
,3
]}

Rozensztajn, N. ^{[3
]}

Ruppert, A. -M. ^{[1
,3
]}

Rabbe, N. ^{[1
]}

Cadranel, J. ^{[1
,3
]}

Wislez, M. ^{[1
,3
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, GRC 04, F-75252 Paris, France

[2] Univ Versailles St Quentin En Yvelines, Hop Ambroise Pare, AP HP, Serv Pneumol & Oncol Thorac,BCOH EA4340, F-92100 Boulogne, France

[3] Hop Tenon, AP HP, Serv Pneumol & Reanimat, F-75970 Paris, France

来源：

REVUE DES MALADIES RESPIRATOIRES | 2015年 / 32卷 / 08期

关键词：

Small cell lung carcinoma; Non-small cell lung carcinoma; Mesotheliama; Sonic Hedgehog; Chemoresistance; SIGNALING PATHWAY; MESENCHYMAL TRANSITION; LUNG FIBROSIS; HUMAN HOMOLOG; EXPRESSION; GROWTH; CELLS; SHH; IDENTIFICATION; REQUIREMENT;

D O I：

10.1016/j.rmr.2014.11.069

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction. Sonic Hedgehog (Shh) pathway is physiologically activated during embryogenesis and development. It plays a role in idiopathic lung fibrosis and is also activated in several solid cancers. State of the art. Shh pathway is reactivated in thoracic cancers, as small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma. Shh pathway is associated with cancer stem cells and seems to have a crucial role in tumor proliferation, aggressiveness and chemoresistance in these cancers. This review describes the activation mode of Shh pathway in thoracic cancers and its role in small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma, using in vitro and in vivo models. Notably, data from literature show that inhibition of Shh pathway has an antitumor action and sensitizes to chemotherapy. Perspectives. These results incite to develop targeted therapies against Shh pathway in the treatment of thoracic cancers. (C) 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：800 / 808

页数：9

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