Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis

被引：7

作者：

Zhou, Tong ^{[1
]}

Li, Xiao ^{[1
]}

Zou, Jie ^{[1
]}

Cai, Minchao ^{[1
]}

Sun, Guizhi ^{[1
]}

Zhang, Yumei ^{[1
]}

Zhao, Yapeng ^{[1
]}

Zhang, Mingjun ^{[2
]}

Zhang, Yanyun ^{[3
,4
,5
]}

Chen, Nan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Nephrol, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Anim Lab, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci, Shanghai 200025, Peoples R China

[5] Chinese Acad Prevent Med, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

DC-SIGN; Dendritic Cells; Renal Tubular Epithelial Cells; Renal Tubulointerstitial Fibrosis; Chronic Kidney Diseases; TUBULAR EPITHELIAL-CELLS; DENDRITIC CELLS; MESENCHYMAL TRANSITION; IMMUNE-RESPONSES; T-CELLS; MECHANISMS; INSIGHTS; GLOMERULONEPHRITIS; RECEPTOR; DISEASE;

D O I：

10.2741/3424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is important for dendritic cell (DC) in migrating, recognizing, capturing, presenting antigens and in initiating T cell responses. In the present study, we investigated the role of DC-SIGN in renal tubulointerstitial inflammation and fibrosis. DC-SIGN was mainly expressed in tubular epithelial cells and DC-SIGN(+) DCs were primarily distributed in renal tubulointerstitial areas during the early stage of nephritis, which was correlated with the degree of renal tubular interstitial lesions and fibrosis. In vitro, DC-SIGN expression in cultured human renal tubular epithelial cells was elevated when treated by tumor necrosis factor-alpha, and was inhibited by anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb). In a rat model of chronic renal interstitial fibrosis, there was a significant correlation of DC-SIGN expression with DC-SIGN(+) DC distribution and the degree of tubulointerstitial lesion. PsL-EGFmAb reduced DC-SIGN expression and DC-SIGN(+) DC accumulation in renal tissues in this rat model. These results suggest that DC-SIGN plays an important role in DC-mediated renal tubular interstitial lesions induced by immuno-inflammatory responses.

引用

页码：2935 / +

页数：10

共 32 条

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