Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy

被引：69

作者：

Kim, Sehoon ^{[1
,2
]}

Ohulchanskyy, Tymish Y. ^{[1
]}

Bharali, Dhruba ^{[1
]}

Chen, Yihui ^{[3
]}

Pandey, Ravindra K. ^{[1
,3
]}

Prasad, Paras N. ^{[1
]}

机构：

[1] SUNY Buffalo, Inst Lasers Photon & Biophoton, Dept Chem, Buffalo, NY 14260 USA

[2] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 136791, South Korea

[3] Roswell Pk Canc Inst, Photodynam Therapy Ctr, New York, NY 14263 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2009年 / 113卷 / 29期

关键词：

DRUG;

D O I：

10.1021/jp900573s

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency Of O-1(2) generation and, thereby, the in vitro PDT efficacy.

引用

页码：12641 / 12644

页数：4

共 26 条

[21] Internal heavy atom effect of Au(III) and Pt(IV) on hypocrellin A for enhanced in vitro photodynamic therapy of cancer
Zhou, Lin
Ge, Xuefeng
Liu, Jihua
Zhou, Jiahong
Wei, Shaohua
Li, Fuyou
Shen, Jian
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (19) : 5317 - 5324
[22] Heavy atom-modified hemicyanine dyes as photosensitizer scaffolds combined with nitric oxide trigger the butterfly effect in tumor therapy
Sheng, Zhijia
Zhao, Chao
Huang, Xiaoyan
Wang, Jing
Liu, Yi
DYES AND PIGMENTS, 2024, 228
[23] Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy
Kim, Sehoon
Ohulchanskyy, Tymish Y.
Pudavar, Haridas E.
Pandey, Ravindra K.
Prasad, Paras N.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) : 2669 - 2675
[24] Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy
Kim, Sehoon
Ohulchanskyy, Tymish Y.
Pudavar, Haridas E.
Pandey, Ravindra K.
Prasad, Paras N.
Journal of the American Chemical Society, 2007, 129 (09): : 2669 - 2675
[25] Naphthalenediimide-based heavy-atom-free nanoparticles for enhanced dual-functional type I photodynamic and photothermal therapy
Min, Suhong
Cao, Lei
Pham, Thanh Chung
Nguyen, Van Kieu Thuy
Kim, Dae Seong
Lee, Sang Gil
Lee, Songyi
SENSORS AND ACTUATORS B-CHEMICAL, 2025, 433
[26] Simultaneous enhanced diagnosis and photodynamic therapy of photosensitizer-doped perylene nanoparticles via doping, fluorescence resonance energy transfer, and antenna effect
Zhang, Jinfeng
An, Feifei
Li, Yanan
Zheng, Caijun
Yang, Yinlong
Zhang, Xiujuan
Zhang, Xiaohong
CHEMICAL COMMUNICATIONS, 2013, 49 (73) : 8072 - 8074

← 1 2 3 →