Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy

被引：69

作者：

Kim, Sehoon ^{[1
,2
]}

Ohulchanskyy, Tymish Y. ^{[1
]}

Bharali, Dhruba ^{[1
]}

Chen, Yihui ^{[3
]}

Pandey, Ravindra K. ^{[1
,3
]}

Prasad, Paras N. ^{[1
]}

机构：

[1] SUNY Buffalo, Inst Lasers Photon & Biophoton, Dept Chem, Buffalo, NY 14260 USA

[2] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 136791, South Korea

[3] Roswell Pk Canc Inst, Photodynam Therapy Ctr, New York, NY 14263 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2009年 / 113卷 / 29期

关键词：

DRUG;

D O I：

10.1021/jp900573s

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report a novel nanoassembly formulation for photodynamic therapy, which is composed of covalently iodine-concentrated organically modified silica (ORMOSIL) nanoparticles (diameter < 30 nm) and a hydrophobic photosensitizer embedded therein. Comparative studies with iodinated and noniodinated nanoparticles have demonstrated that the intraparticle external heavy-atom effect on the encapsulated photosensitizer molecules significantly enhances the efficiency Of O-1(2) generation and, thereby, the in vitro PDT efficacy.

引用

页码：12641 / 12644

页数：4

共 26 条

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