BRCAness revisited

被引：977

作者：

Lord, Christopher J. ^{[1
,2
]}

Ashworth, Alan ^{[3
]}

机构：

[1] Inst Canc Res, Canc Res UK Gene Funct Lab, London SW3 6JB, England

[2] Inst Canc Res, Res Ctr, London SW3 6JB, England

[3] Univ Calif San Francisco, UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 02期

基金：

英国惠康基金;

关键词：

HOMOLOGOUS RECOMBINATION DEFICIENCY; EPITHELIAL OVARIAN-CANCER; NEGATIVE BREAST-CANCER; DNA-DAMAGE RESPONSE; EX-VIVO ASSAY; POLY(ADP-RIBOSE) POLYMERASE; MUTATIONAL PROCESSES; GENOMIC INSTABILITY; SOMATIC MUTATIONS; MUTANT-CELLS;

D O I：

10.1038/nrc.2015.21

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past 20 years, there has been considerable progress in our understanding of the biological functions of the BRCA1 and BRCA2 cancer susceptibility genes. This has led to the development of new therapeutic approaches that target tumours with loss-of-function mutations in either BRCA1 or BRCA2. Tumours that share molecular features of BRCA-mutant tumours - that is, those with 'BRCAness' - may also respond to similar therapeutic approaches. Several paradigm shifts require a reassessment of the concept of BRCAness, how this property is assayed and its relevance to our understanding of tumour biology and the treatment of cancer.

引用

页码：110 / 120

页数：11

共 101 条

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