Molecular targets of luteolin in cancer

被引：139

作者：

Tuorkey, Muobarak J. ^{[1
]}

机构：

[1] Damanhour Univ, Dept Zool, Fac Sci, Div Physiol, Damanhour 22111, Al Behira, Egypt

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2016年 / 25卷 / 01期

关键词：

cell cycle arrest; DNA methylation; histone modification; PI3K; Akt; mTOR pathway; Wnt; -catenin signaling; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CELL CONTACT; ENDOPLASMIC-RETICULUM STRESS; LUNG-CARCINOMA CELLS; FATTY-ACID SYNTHASE; HUMAN TUMOR-CELLS; KAPPA-B PATHWAY; INDUCED APOPTOSIS; DOWN-REGULATION; GROWTH-FACTOR;

D O I：

10.1097/CEJ.0000000000000128

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many food-derived phytochemical compounds and their derivatives represent a cornucopia of new anticancer compounds. Despite extensive study of luteolin, the literature has no information on the exact mechanisms or molecular targets through which it deters cancer progression. This review discusses existing data on luteolin's anticancer activities and then offers possible explanations for and molecular targets of its cancer-preventive action. Luteolin prevents tumor development largely by inactivating several signals and transcription pathways essential for cancer cells. This review also offers insights into the molecular mechanisms and targets through which luteolin either prevents cancer or mediates cancer cell death.

引用

页码：65 / 76

页数：12

共 128 条

[1]

Abdel-Magid AF, 2014, ACS MED CHEM LETT, V5, P456, DOI [10.1021/ml5000838, 10.1021/ml500276a]

[2] Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells [J].

Aleksic, Tamara ;

Chitnis, Meenali M. ;

Perestenko, Olga V. ;

Gao, Shan ;

Thomas, Peter H. ;

Turner, Gareth D. ;

Protheroe, Andrew S. ;

Howarth, Mark ;

Macaulay, Valentine M. .

CANCER RESEARCH, 2010, 70 (16) :6412-6419

[3] Enhanced Anti-tumor Activity by the Combination of the Natural Compounds (-)-Epigallocatechin-3-gallate and Luteolin POTENTIAL ROLE OF p53 [J].

Amin, A. R. M. Ruhul ;

Wang, Dongsheng ;

Zhang, Hongzheng ;

Peng, Shifang ;

Shin, Hyung Ju C. ;

Brandes, Johann C. ;

Tighiouart, Mourad ;

Khuri, Fadlo R. ;

Chen, Zhuo Georgia ;

Shin, Dong M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (45) :34557-34565

[4]

[Anonymous], EVID BASED COMPLEMEN

[5]

[Anonymous], EVID BASED COMPLEMEN

[6] Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells [J].

Attoub, Samir ;

Hassan, Ahmed H. ;

Vanhoecke, Barbara ;

Iratni, Rabah ;

Takahashi, Takashi ;

Gaben, Anne-Marie ;

Bracke, Marc ;

Awad, Salma ;

John, Anne ;

Kamalboor, Hamda Ahmed ;

Al Sultan, Mahmood Ahmed ;

Arafat, Kholoud ;

Gespach, Christian ;

Petroianu, Georg .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 651 (1-3) :18-25

[7] Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death [J].

Beck, Raphael ;

Verrax, Julien ;

Gonze, Thomas ;

Zappone, Marianne ;

Pedrosa, Rozangela Curi ;

Taper, Henryk ;

Feron, Olivier ;

Calderon, Pedro Buc .

BIOCHEMICAL PHARMACOLOGY, 2009, 77 (03) :375-383

[8] Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell cell contact [J].

Borchers, AH ;

Sanders, LA ;

Bowden, GT .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1997, 123 (01) :13-20

[9] The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells [J].

Cai, Xueting ;

Lu, Wuguang ;

Ye, Tingmei ;

Lu, Min ;

Wang, Jianhua ;

Huo, Jiege ;

Qian, Shihui ;

Wang, Xiaoning ;

Cao, Peng .

ONCOLOGY REPORTS, 2012, 28 (04) :1353-1361

[10] Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells [J].

Cai, Xueting ;

Ye, Tingmei ;

Liu, Chao ;

Lu, Wuguang ;

Lu, Min ;

Zhang, Juan ;

Wang, Min ;

Cao, Peng .

TOXICOLOGY IN VITRO, 2011, 25 (07) :1385-1391

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