The dynamin family of mechanoenzymes: pinching in new places

被引：297

作者：

McNiven, MA ^{[1
]}

Cao, H ^{[1
]}

Pitts, KR ^{[1
]}

Yoon, Y ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Ctr Basic Res Digest Dis, Rochester, MN 55905 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(99)01538-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.

引用

页码：115 / 120

页数：6

共 54 条

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