Synthesis of 3-(4-substituted benzoylmethyl)-2-benzoxazolinones and screening antimicrobial activities

被引：18

作者：

Köksal, M

Gökhan, N

Erdogan, H ^{[1
]}

Özalp, M

Ekizoglu, M

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-06100 Ankara, Turkey

来源：

FARMACO | 2002年 / 57卷 / 07期

关键词：

3-substituted-2-benzoxazolinones; synthesis; antibacterial agents; antifungal agents;

D O I：

10.1016/S0014-827X(02)01244-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of 3-(4-substituted benzoylmethyl)-2-benzoxazolinones have been synthesized by reacting with 2-benzoxazolinone and 4-substituted phenacyl bromide in ethanol. Their chemical structures were confirmed by IR, H-1 NMR and elemental analysis. For screening antimicrobial activity, minimum inhibitory concentration (MIC) values were determined against two Gram positive, one Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and three yeast-like the fungi (Candida albicans, Candida krusei, Candida parapsilosis). (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

引用

页码：535 / 538

页数：4

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