Application of Methyl Bisphosphine-Ligated Palladium Complexes for Low Pressure N-11C-Acetylation of Peptides

被引：31

作者：

Andersen, Thomas L. ^{[1
,2
]}

Nordeman, Patrik ^{[3
]}

Christoffersen, Heidi F. ^{[1
,2
]}

Audrain, Helene ^{[4
,5
]}

Antoni, Gunnar ^{[3
]}

Skrydstrup, Troels ^{[1
,2
]}

机构：

[1] Aarhus Univ, Carbon Dioxide Activat Ctr CADIAC, Dept Chem, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

[3] Uppsala Univ, Dept Med Chem, S-75123 Uppsala, Sweden

[4] Aarhus Univ Hosp, Dept Nucl Med, DK-8000 Aarhus, Denmark

[5] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

C-11-labeling; carbonylation; palladium; peptides; CARBONYLATION REACTIONS; CARBON-MONOXIDE; ANTIMICROBIAL PEPTIDES; RADIOLABELED PEPTIDES; PET; RADIOPHARMACEUTICALS; PEPTAIBOLS; ANALOGS; SCOPE; CYCLOISOMERIZATION;

D O I：

10.1002/anie.201700446

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and effective method is described for C-11-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [C-11] carbon monoxide. The protocol facilitates the production of native N-C-11-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.

引用

页码：4549 / 4553

页数：5

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