Novel Three-Component Annulation for the Synthesis of 2,4,6-Triarylpyrimidines under Solvent-Free and Catalyst-Free Conditions

被引：1

作者：

Ding, Yuxin ^{[1
,2
]}

Ma, Yongmin ^{[1
,2
]}

Chen, Jing ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 40卷 / 12期

关键词：

catalyst-free; solvent-free; one-pot; three-component reaction; 2,4,6-triarylpyrimidine; ANTITUMOR-ACTIVITY; PYRIMIDINES; DESIGN;

D O I：

10.6023/cjoc202005078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This "green" methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

引用

页码：4357 / 4363

页数：7

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