Hydroxybutyl starch-based thermosensitive hydrogel for protein separation

被引：19
作者：
Dong, Shiting [1 ,2 ]
Li, Sai [1 ,2 ]
Hao, Yacheng [1 ,2 ]
Gao, Qunyu [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Carbohydrate Lab, Guangzhou 510640, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 134卷
关键词：
Thermosensitive hydrogel; Hydroxybutyl starch; Protein separation; DELIVERY; ALBUMIN; OXIDE;
D O I：
10.1016/j.ijbiomac.2019.04.206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The starch-based thermosensitive hydrogel (STH) is a new type of polymer material with great water-absorbing ability. In this study, a series of STHs was synthesized based on hydroxybutyl starch (HS) and polyethylene glycol (PEG). Furthermore, bovine serum albumin (BSA) was used as a model protein for separation from produced hydrogels. This STH exhibited a reversible swelling and deswelling as the temperature changed. It was found that the addition of HS and PEG resulted in more microporous structures and increasing equilibrium swelling ratio (ESR). The improved performance, simple method and low-cost material conferred STH to serve as a considerable biomaterial for protein separation. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
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