Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides

被引：48

作者：

Serrano, Griselda N. ^{[1
]}

Zhanel, George G. ^{[2
]}

Schweizer, Frank ^{[1
,2
]}

机构：

[1] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3A 1R9, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ANTIMICROBIAL PEPTIDES; AMINO-ACIDS; LIPOPEPTIDES; ANTIFUNGAL; ENHANCEMENT; PATHOGENS; CHAIN; MODE;

D O I：

10.1128/AAC.01100-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

引用

页码：2215 / 2217

页数：3

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