The first unique synthetic mycobacterial cord factors

被引：24

作者：

Al Dulayymi, Juma'a R. ^{[1
]}

Baird, Mark S. ^{[1
]}

Maza-Iglesias, Maximiliano ^{[1
]}

Vander Beken, Seppe ^{[2
]}

Grooten, Johan ^{[2
]}

机构：

[1] Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales

[2] Univ Ghent, Dept Mol Biol, Fac Sci, Ghent, Belgium

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

关键词：

FACTOR TREHALOSE 6,6'-DIMYCOLATE; INFLUENZA-VIRUS INFECTION; TOF MASS-SPECTROMETRY; NECROSIS-FACTOR-ALPHA; MYCOLIC ACIDS; FACTOR TREHALOSE-6,6'-DIMYCOLATE; SINGLE ENANTIOMERS; MURINE MACROPHAGES; TUBERCULOSIS; MICE;

D O I：

10.1016/j.tetlet.2009.03.213

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic mycolic acids matching the overall structure of the major alpha- and methoxy-mycolic acids of Mycobacterium tuberculosis are coupled to trehalose to generate the corresponding synthetic trehalose dimycolate (TDM; cord factor) and trehalose monomycolate (TMM). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3702 / 3705

页数：4

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