Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases

被引：9

作者：

Basu, Ashis K. ^{[1
]}

Pande, Paritosh ^{[1
]}

Bose, Arindam ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2017年 / 30卷 / 01期

关键词：

CELL NUCLEAR ANTIGEN; SIMIAN KIDNEY-CELLS; ERROR-FREE REPLICATION; DISPLACED INTERCALATED STRUCTURE; INDUCED FRAMESHIFT MUTAGENESIS; UBIQUITIN-BINDING DOMAINS; SITE-SPECIFIC MUTAGENESIS; THYMINE-THYMINE DIMER; Y-FAMILY; MAMMALIAN-CELLS;

D O I：

10.1021/acs.chemrestox.6b00285

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the discovery of translesion synthesis DNA polymerases, great strides have been made in the last two decades in understanding the mode of replication of various DNA lesions in prokaryotes and eukaryotes. A database search indicated that approximately 2000 articles on this topic have been published in this period. This includes research involving genetic and structural, studies as well as in vitro experiments using purified DNA polymerases and accessory proteins. It is a daunting task to comprehend this exciting and rapidly emerging area of research. Even so, as the majority of DNA damage, occurs at 2'-deoxyguanosine residues, this perspective attempts to summarize a subset of this field, focusing on the most relevant eukaryotic DNA polymerases responsible for their bypass.

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收藏

页码：61 / 72

页数：12

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