Thrombotic Thrombocytopenic Purpura: 2012 American Society for Apheresis (ASFA) Consensus Conference on Classification, Diagnosis, Management, and Future Research

被引:94
作者
Sarode, Ravi [1 ]
Bandarenko, Nick [2 ]
Brecher, Mark E. [3 ,4 ]
Kiss, Joseph E. [5 ,6 ,7 ]
Marques, Marisa B. [8 ]
Szczepiorkowski, Zbigniew M. [9 ,10 ]
Winters, Jeffrey L. [11 ]
机构
[1] UT Southwestern Med Ctr, Dept Pathol, Div Transfus Med & Hemostasis, Dallas, TX 75235 USA
[2] Duke Univ, Med Ctr, Durham, NC USA
[3] Lab Corp Amer, Burlington, NC USA
[4] Univ N Carolina, Chapel Hill, NC USA
[5] Univ Pittsburgh, Inst Transfus Med, Hemapheresis Serv, Pittsburgh, PA 15260 USA
[6] Univ Pittsburgh, Inst Transfus Med, Blood Serv, Pittsburgh, PA 15260 USA
[7] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA
[8] Univ Alabama Birmingham, Dept Pathol, Div Lab Med, Birmingham, AL 35294 USA
[9] Dartmouth Hitchcock Med Ctr, Dept Pathol, Lebanon, NH 03766 USA
[10] Dartmouth Hitchcock Med Ctr, Dept Med, Lebanon, NH 03766 USA
[11] Mayo Clin, Dept Lab Med & Pathol, Div Transfus Med, Rochester, MN USA
关键词
ADAMTS13; microangiopathic hemolytic anemia; thrombotic thrombocytopenic purpura; therapeutic plasma exchange; Upshaw Shulman Syndrome; VON-WILLEBRAND-FACTOR; FACTOR-CLEAVING PROTEASE; HEMOLYTIC-UREMIC SYNDROME; ADAMTS-13 ACTIVITY MEASUREMENT; PLASMA-EXCHANGE; VONWILLEBRAND-FACTOR; FACTOR-VIII; ANTI-ADAMTS13; ANTIBODIES; FRETS-VWF73; ASSAY; APTAMER ARC1779;
D O I
10.1002/jca.21302
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The American Society for Apheresis (ASFA) conducted a 1 day consensus conference on Thrombotic Thrombocytopenic Purpura (TTP) during its annual meeting in Atlanta, GA, on April 10, 2012. The authors of this article, a subcommittee of ASFA's Clinical Applications Committee, developed several questions with regard to definitions, classification, pathophysiology, diagnosis, management, and future research in TTP. These questions were provided to the seven invited speakers who are the experts in the field of TTP. Two moderators conducted the proceedings of the conference which was attended by more than 100 participants. After each presentation, there was an open discussion that included moderator-selected written questions submitted by the audience. A medical writer-generated transcript of the proceedings as well as each presentation was made available to the authors. Each summary was reviewed and approved by the respective speaker before submission of this article. The subcommittee also developed seven key questions for blinded, electronic polling conducted by the moderators to generate a consensus amongst the speakers. This article includes these presentation summaries as well as results of the electronic poll. (C) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:148 / 167
页数:20
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