Microbial models of animal drug metabolism - Part 5. Microbial preparation of human hydroxylated metabolites of irbesartan

被引：4

作者：

Alexandre, V ^{[1
]}

Ladril, S ^{[1
]}

Maurs, M ^{[1
]}

Azerad, R ^{[1
]}

机构：

[1] Univ Paris 05, Chim & Biochim Pharmacol & Toxicol Lab, UMR 8601, F-75006 Paris, France

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2004年 / 29卷 / 1-6期

关键词：

bacteria; drug metabolism; fungi; glucoside; hydroxylation; whole-cell biocatalysis;

D O I：

10.1016/j.molcatb.2004.01.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An exhaustive screening of fungal and microbial strains allowed to select the best microorganisms to produce in high yields some of the animal metabolites of an antihypertensive drug, irbesartan, in order to elucidate their structural and stereochemical characteristics. Among the microorganisms tested, bacteria, and especially Streptomyces strains, were the most active producers of the main metabolites which included diastereomeric derivatives hydroxylated in the spirocyclopentane ring, open rearranged hydroxylated derivatives, and a putative N-glycosidic conjugate of irbesartan. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：173 / 179

页数：7

共 21 条

[1]

Azerad R, 1999, Adv Biochem Eng Biotechnol, V63, P169

[2]

Bourrié M, 1999, DRUG METAB DISPOS, V27, P288

[3] The new angiotensin II receptor antagonist, irbesartan - Pharmacokinetic and pharmacodynamic considerations [J].

Brunner, HR .

AMERICAN JOURNAL OF HYPERTENSION, 1997, 10 (12) :311S-317S

[4]

CANNELL RJP, 1995, DRUG METAB DISPOS, V23, P724

[5]

Chando TJ, 1998, DRUG METAB DISPOS, V26, P408

[6]

CHEM SS, 1991, Patent No. 5057522

[7]

Chen S. T., 1992, Merck) US Patent, Patent No. 5132216

[8]

CHEN SST, 1993, Patent No. 5214153

[9]

CHEN SST, 1991, Patent No. 5066586

[10]

CHEN SST, 1993, Patent No. 5217882

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