Targeting transcription is no longer a quixotic quest

被引：19

作者：

Mapp, Anna K. ^{[1
,2
]}

Pricer, Rachel ^{[1
,2
]}

Sturlis, Steven ^{[1
,2
]}

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 12期

关键词：

SMALL-MOLECULE; MULTIPROTEIN COMPLEXES; KIX DOMAIN; PROTEIN; COACTIVATOR; MECHANISMS; INHIBITORS; CBP/P300; LIGAND; P53;

D O I：

10.1038/nchembio.1962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

引用

页码：891 / 894

页数：4

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