One-Pot Synthesis of N-(Imidazo[1,2-a]pyridin-3-yl)-Substituted Sulfonamides Using Catalytic Zinc Chloride

被引：20

作者：

Yu, Chuanming ^{[1
]}

Chen, Xu ^{[1
]}

Wu, Ran ^{[1
]}

Yang, Guanghui ^{[1
]}

Shi, Jiaoyong ^{[1
]}

Pan, Lingling ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Minist Educ, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol Related Equipmen, Hangzhou 310014, Zhejiang, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Zinc; Nitrogen heterocycles; Sulfonamides; ANTITUMOR EVALUATION; C-NUCLEOSIDES; DERIVATIVES; AMINOPYRIDINES; AMINATION; IMINES; PART; DNA;

D O I：

10.1002/ejoc.201301612

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot two-step synthesis of N-(imidazo[1,2-a]pyridin-3-yl)sulfonamides from easily available arylglyoxal hydrates, 2-aminopyridines, and sulfonamides has been developed. The procedure, using zinc chloride as catalyst, is simple and inexpensive. The desired products were obtained in moderate to good yields under the optimized reaction conditions.

引用

收藏

页码：2037 / 2043

页数：7

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