The histone variant H2A.Z is dynamically expressed in the developing mouse placenta and in differentiating trophoblast stem cells

被引：4
作者：
Kafer, Georgia R. [1 ,2 ]
Carlton, Peter M. [1 ]
Lehnert, Sigrid A. [3 ]
机构：
[1] Kyoto Univ, Inst Integrated Cell Mat Sci ICeMS, Kyoto, Japan
[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia
[3] Commonwealth Sci & Ind Res Org CSIRO, Agr Flagship, St Lucia, Qld 4067, Australia
来源：
PLACENTA | 2015年 / 36卷 / 11期
基金：
日本学术振兴会;
关键词：
H2A.Z; Placenta; Trophoblast; Differentiation; Progenitor; EARLY MAMMALIAN DEVELOPMENT; GENES;
D O I：
10.1016/j.placenta.2015.08.018
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The histone variant H2A.Z is important in establishing new chromatin environments necessary for permitting changes in gene expression and thus differentiation in mouse embryonic stem (mES) cells. In this study we show that H2A.Z is highly expressed in the early mouse placenta, and is specifically limited to progenitor-like trophoblast cells. Using in vitro models, we revealed distinct differences in H2A.Z abundance between undifferentiated, differentiating and differentiated mouse trophoblast stem (mTS) cells. Our work supports the hypothesis that in addition to roles in differentiating mES cells, H2A.Z is also involved in the differentiation of extra-embryonic tissues. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：1325 / 1328
页数：4
相关论文
共 15 条
[1]   The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta [J].
Anson-Cartwright, L ;
Dawson, K ;
Holmyard, D ;
Fisher, SJ ;
Lazzarini, RA ;
Cross, JC .
NATURE GENETICS, 2000, 25 (03) :311-314
[2]   H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment [J].
Creyghton, Menno P. ;
Markoulaki, Styliani ;
Levine, Stuart S. ;
Hanna, Jacob ;
Lodato, Michael A. ;
Sha, Ky ;
Young, Richard A. ;
Jaenisch, Rudolf ;
Boyer, Laurie A. .
CELL, 2008, 135 (04) :649-661
[3]   Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning [J].
Donnison, M ;
Beaton, A ;
Davey, HW ;
Broadhurst, R ;
L'Huillier, P ;
Pfeffer, PL .
DEVELOPMENT, 2005, 132 (10) :2299-2308
[4]   Histone variant H2A.Z is required for early mammalian development [J].
Faast, R ;
Thonglairoam, V ;
Schulz, TC ;
Beall, J ;
Wells, JRE ;
Taylor, H ;
Matthaei, K ;
Rathjen, PD ;
Tremethick, DJ ;
Lyons, I .
CURRENT BIOLOGY, 2001, 11 (15) :1183-1187
[5]   Expression of genes coding for histone variants and histone-associated proteins in pluripotent stem cells and mouse preimplantation embryos [J].
Kafer, Georgia R. ;
Lehnert, Sigrid A. ;
Pantaleon, Marie ;
Kaye, Peter L. ;
Moser, Ralf J. .
GENE EXPRESSION PATTERNS, 2010, 10 (06) :299-305
[6]  
Ku MC, 2012, GENOME BIOL, V13, DOI [10.1186/gb-2012-13-10-r85, 10.1186/gb-2012-13-10-R85]
[7]   Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta [J].
Luo, JM ;
Sladek, R ;
Bader, JA ;
Matthyssen, A ;
Rossant, J ;
Giguere, V .
NATURE, 1997, 388 (6644) :778-782
[8]   Histone variant H2A.Z marks the 5′ ends of both active and inactive genes in euchromatin [J].
Raisner, RM ;
Hartley, PD ;
Meneghini, MD ;
Bao, MZ ;
Liu, CL ;
Schreiber, SL ;
Rando, OJ ;
Madhani, HD .
CELL, 2005, 123 (02) :233-248
[9]   Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development [J].
Rangasamy, D ;
Berven, L ;
Ridgway, P ;
Tremethick, DJ .
EMBO JOURNAL, 2003, 22 (07) :1599-1607
[10]   Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta [J].
Simmons, David G. ;
Fortier, Amanda L. ;
Cross, James C. .
DEVELOPMENTAL BIOLOGY, 2007, 304 (02) :567-578
12