Role of the ram domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage

被引：14
作者：
Deregowski, Valerie
Gazzerro, Elisabetta
Priest, Leah
Rydziel, Sheila
Canalis, Ernesto [1 ]
机构：
[1] St Francis Hosp & Med Ctr, Dept Res, Hartford, CT 06105 USA
[2] Univ Connecticut, Sch Med, Farmington, CT USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 08期
关键词：
notch; osteoblast differentiation; Wnt; HES-1; signaling;
D O I：
10.1359/JBMR.060505
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Notch proteins belong to a family of single pass transmembrane receptors that are activated after interactions with the membrane-bound ligands Delta and Jagged/Serrate. We determined the pathways responsible for the inhibitory effects of Notch on osteoblastogenesis and the contributions of the RAM domain and ankyrin repeats to this process in cells of the osteoblastic lineage.
引用
收藏
页码：1317 / 1326
页数：10
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