Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma

被引：15
作者：
Piao, W. [1 ]
Chau, D. [1 ]
Yue, L. M. [1 ]
Kwong, Y-L [1 ]
Tse, E. [1 ]
机构：
[1] Univ Hong Kong, Dept Med, Div Haematol, Hong Kong, Hong Kong, Peoples R China
来源：
LEUKEMIA | 2017年 / 31卷 / 02期
关键词：
MEDIATED LYMPHOMAGENESIS; RETINOIC ACID; AML CELLS; PATHOBIOLOGY; ONCOPROTEIN; APOPTOSIS; TARGET; AS2O3;
D O I：
10.1038/leu.2016.311
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：522 / 526
页数：6
相关论文
共 15 条
  • [1] Pathobiology of ALK+ anaplastic large-cell lymphoma
    Amin, Hesham M.
    Lai, Raymond
    [J]. BLOOD, 2007, 110 (07) : 2259 - 2267
  • [2] Arsenic trioxide: safety issues and their management
    Au, Wing-Yan
    Kwong, Yok-Lam
    [J]. ACTA PHARMACOLOGICA SINICA, 2008, 29 (03) : 296 - 304
  • [3] Chen GQ, 1997, BLOOD, V89, P3345
  • [4] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
    Chiarle, R
    Simmons, WJ
    Cai, HY
    Dhall, G
    Zamo', A
    Raz, R
    Karras, JG
    Levy, DE
    Inghirami, G
    [J]. NATURE MEDICINE, 2005, 11 (06) : 623 - 629
  • [5] Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity
    Diaz, Z.
    Laurenzana, A.
    Mann, K. K.
    Bismar, T. A.
    Schipper, H. M.
    Miller, W. H., Jr.
    [J]. LEUKEMIA, 2007, 21 (10) : 2117 - 2127
  • [6] Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas
    Drexler, HG
    Gignac, SM
    von Wasielewski, R
    Werner, M
    Dirks, WG
    [J]. LEUKEMIA, 2000, 14 (09) : 1533 - 1559
  • [7] Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells
    El Hajj, Hiba
    Dassouki, Zeina
    Berthier, Caroline
    Raffoux, Emmanuel
    Ades, Lionel
    Legrand, Olivier
    Hleihel, Rita
    Sahin, Umut
    Tawil, Nadim
    Salameh, Ala
    Zibara, Kazem
    Darwiche, Nadine
    Mohty, Mohamad
    Dombret, Herve
    Fenaux, Pierre
    de The, Hugues
    Bazarbachi, Ali
    [J]. BLOOD, 2015, 125 (22) : 3447 - 3454
  • [8] PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3
    Jeanne, Marion
    Lallemand-Breitenbach, Valerie
    Ferhi, Omar
    Koken, Marcel
    Le Bras, Morgane
    Duffort, Stephanie
    Peres, Laurent
    Berthier, Caroline
    Soilihi, Hassane
    Raught, Brian
    de The, Hugues
    [J]. CANCER CELL, 2010, 18 (01) : 88 - 98
  • [9] Survival of Patients With Peripheral T-Cell Lymphoma After First Relapse or Progression: Spectrum of Disease and Rare Long-Term Survivors
    Mak, Vivien
    Hamm, Jeremey
    Chhanabhai, Mukesh
    Shenkier, Tamara
    Klasa, Richard
    Sehn, Laurie H.
    Villa, Diego
    Gascoyne, Randy D.
    Connors, Joseph M.
    Savage, Kerry J.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (16) : 1970 - +
  • [10] Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells
    Martelli, Maria Paola
    Gionfriddo, Ilaria
    Mezzasoma, Federica
    Milano, Francesca
    Pierangeli, Sara
    Mulas, Floriana
    Pacini, Roberta
    Tabarrini, Alessia
    Pettirossi, Valentina
    Rossi, Roberta
    Vetro, Calogero
    Brunetti, Lorenzo
    Sportoletti, Paolo
    Tiacci, Enrico
    Di Raimondo, Francesco
    Falini, Brunangelo
    [J]. BLOOD, 2015, 125 (22) : 3455 - 3465
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