Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence

被引：28

作者：

Harrison, Odile B. ^{[2
]}

Evans, Nicholas J. ^{[4
]}

Blair, Jessica M. ^{[2
]}

Grimes, Holly S. ^{[2
]}

Tinsley, Colin R. ^{[5
]}

Nassif, Xavier ^{[6
]}

Kriz, Paula ^{[7
]}

Ure, Roisin ^{[2
]}

Gray, Steve J. ^{[3
]}

Derrick, Jeremy P. ^{[4
]}

Maiden, Martin C. J. ^{[2
]}

Feavers, Ian M. ^{[1
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Bacteriol, S Mimms, Herts, England

[2] Univ Oxford, Dept Zool, Oxford OX1 2JD, England

[3] Manchester Royal Infirm, Hlth Protect Agcy, RSID, Meningococcal Reference Unit, Manchester, Lancs, England

[4] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[5] AgroParisTech, Lab Microbiol & Genet Mol, Thiverval Grignon, France

[6] Inst Natl Sante & Rech Med, U570, Fac Med Necker, Paris, France

[7] Natl Inst Publ Hlth, Natl Reference Lab Meningococcal Infect, Prague, Czech Republic

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 01期

基金：

英国惠康基金;

关键词：

NEISSERIA-MENINGITIDIS; PATHOGENICITY ISLANDS; EVOLUTION; MICROBES; PROTEIN;

D O I：

10.1086/599377

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

引用

页码：94 / 98

页数：5

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