Common Carotid Intima-Media Thickness Measurements Do Not Improve Cardiovascular Risk Prediction in Individuals With Elevated Blood Pressure The USE-IMT Collaboration

被引：60

作者：

Bots, Michiel L. ^{[1
]}

Groenewegen, Karlijn A. ^{[1
]}

Anderson, Todd J. ^{[3
,4
]}

Britton, Annie R. ^{[5
]}

Dekker, Jacqueline M. ^{[6
]}

Engstrom, Gunnar ^{[6
,7
]}

Evans, Greg W. ^{[8
]}

de Graaf, Jacqueline ^{[9
]}

Grobbee, Diederick E. ^{[1
,27
]}

Hedblad, Bo

Hofman, Albert ^{[10
,11
,12
]}

Holewijn, Suzanne ^{[9
]}

Ikeda, Ai ^{[13
]}

Kavousi, Maryam ^{[10
,11
,12
]}

Kitagawa, Kazuo ^{[14
]}

Kitamura, Akihiko ^{[13
]}

Ikram, M. Arfan ^{[10
,11
,12
]}

Lonn, Eva M. ^{[15
,16
]}

Lorenz, Matthias W. ^{[17
]}

Mathiesen, Ellisiv B. ^{[18
]}

Nijpels, Giel

Okazaki, Shuhei ^{[14
]}

O'Leary, Daniel H. ^{[19
]}

Polak, Joseph F. ^{[19
]}

Price, Jacqueline F. ^{[20
]}

Robertson, Christine ^{[20
]}

Rembold, Christopher M. ^{[21
]}

Rosvall, Maria ^{[7
,17
,23
]}

Rundek, Tatjana ^{[26
]}

Salonen, Jukka T. ^{[22
]}

Sitzer, Matthias

Stehouwer, Coen D. A. ^{[24
,25
]}

Franco, Oscar H. ^{[10
,11
,12
]}

Peters, Sanne A. E. ^{[1
]}

den Ruijter, Hester M. ^{[1
,2
]}

机构：

[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Expt Cardiol, NL-3584 CX Utrecht, Netherlands

[3] Univ Calgary, Dept Cardiac Sci, Calgary, AB T2N 1N4, Canada

[4] Univ Calgary, Libin Cardiovasc Inst Alberta, Calgary, AB T2N 1N4, Canada

[5] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England

[6] Vrije Univ Amsterdam Med Ctr, Inst Hlth & Care Res, Amsterdam, Netherlands

[7] Lund Univ, Dept Clin Sci Malmo, Skane Univ Hosp, S-22100 Lund, Sweden

[8] Wake Forest Sch Med, Dept Biostat Sci & Neurol, Winston Salem, NC USA

[9] Radboud Univ Nijmegen, Med Ctr, Div Vasc Med, Dept Gen Internal Med, NL-6525 ED Nijmegen, Netherlands

[10] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[11] Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands

[12] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[13] Osaka Med Ctr Hlth Sci & Promot, Osaka, Japan

[14] Osaka Univ, Grad Sch Med, Dept Neurol, Stroke Ctr, Suita, Osaka 565, Japan

[15] McMaster Univ, Dept Med, Div Cardiol, Hamilton, ON, Canada

[16] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada

[17] Goethe Univ Frankfurt, Univ Hosp, Dept Neurol, D-60054 Frankfurt, Germany

[18] Univ Tromso, Dept Clin Med, Brain & Circulat Res Grp, Tromso, Norway

[19] Tufts Med Ctr, Dept Radiol, Boston, MA USA

[20] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland

[21] Univ Virginia, Dept Internal Med, Div Cardiol, Charlottesville, VA USA

[22] MAS Metab Analyt Serv Oy, Helsinki, Finland

[23] Klinikum Herford, Dept Neurol, Herford, Germany

[24] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands

[25] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

[26] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[27] Univ Malaya, Med Ctr, Kuala Lumpur, Malaysia

来源：

HYPERTENSION | 2014年 / 63卷 / 06期

关键词：

atherosclerosis; carotid intima-media thickness; primary prevention; prognosis; risk; JOINT-NATIONAL-COMMITTEE; CORONARY-HEART-DISEASE; TASK-FORCE; ARTERIAL-HYPERTENSION; PRACTICE GUIDELINES; VASCULAR EVENTS; 7TH REPORT; ATHEROSCLEROSIS; PREVENTION; PLAQUE;

D O I：

10.1161/HYPERTENSIONAHA.113.02683

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Carotid intima-media thickness (CIMT) is a marker of cardiovascular risk. It is unclear whether measurement of mean common CIMT improves 10-year risk prediction of first-time myocardial infarction or stroke in individuals with elevated blood pressure. We performed an analysis among individuals with elevated blood pressure (ie, a systolic blood pressure 140 mm Hg and a diastolic blood pressure 90 mm Hg) in USE-IMT, a large ongoing individual participant data meta-analysis. We refitted the risk factors of the Framingham Risk Score on asymptomatic individuals (baseline model) and expanded this model with mean common CIMT (CIMT model) measurements. From both models, 10-year risks to develop a myocardial infarction or stroke were estimated. In individuals with elevated blood pressure, we compared discrimination and calibration of the 2 models and calculated the net reclassification improvement (NRI). We included 17 254 individuals with elevated blood pressure from 16 studies. During a median follow-up of 9.9 years, 2014 first-time myocardial infarctions or strokes occurred. The C-statistics of the baseline and CIMT models were similar (0.73). NRI with the addition of mean common CIMT was small and not significant (1.4%; 95% confidence intervals, -1.1 to 3.7). In those at intermediate risk (n=5008, 10-year absolute risk of 10% to 20%), the NRI was 5.6% (95% confidence intervals, 1.6-10.4). There is no added value of measurement of mean common CIMT in individuals with elevated blood pressure for improving cardiovascular risk prediction. For those at intermediate risk, the addition of mean common CIMT to an existing cardiovascular risk score is small but statistically significant.

引用

页码：1173 / 1181

页数：9

共 42 条

[1] Prediction of major adverse cardiovascular events by age-normalized carotid intimal medial thickness [J].

Ali, Yasmine S. ;

Rembold, Karen E. ;

Weaver, Brad ;

Wills, Mary Beth ;

Tatar, Steven ;

Ayers, Carlos R. ;

Rembold, Christopher M. .

ATHEROSCLEROSIS, 2006, 187 (01) :186-190

[2] Microvascular Function Predicts Cardiovascular Events in Primary Prevention Long-Term Results From the Firefighters and Their Endothelium (FATE) Study [J].

Anderson, Todd J. ;

Charbonneau, Francois ;

Title, Lawrence M. ;

Buithieu, Jean ;

Rose, M. Sarah ;

Conradson, Heather ;

Hildebrand, Kathy ;

Fung, Marinda ;

Verma, Subodh ;

Lonn, Eva M. .

CIRCULATION, 2011, 123 (02) :163-169

[3] Measurements of Carotid Intima-Media Thickness and of Interadventitia Common Carotid Diameter Improve Prediction of Cardiovascular Events Results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) Study [J].

Baldassarre, Damiano ;

Hamsten, Anders ;

Veglia, Fabrizio ;

de Faire, Ulf ;

Humphries, Steve E. ;

Smit, Andries J. ;

Giral, Philippe ;

Kurl, Sudhir ;

Rauramaa, Rainer ;

Mannarino, Elmo ;

Grossi, Enzo ;

Paoletti, Rodolfo ;

Tremoli, Elena .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (16) :1489-1499

[4] Screening for Cardiovascular Risk in Asymptomatic Patients [J].

Berger, Jeffrey S. ;

Jordan, Courtney O. ;

Lloyd-Jones, Donald ;

Blumenthal, Roger S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (12) :1169-1177

[5] Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality - The cardiovascular health study [J].

Cao, Jie J. ;

Arnold, Alice M. ;

Manolio, Teri A. ;

Polak, Joseph F. ;

Psaty, Bruce M. ;

Hirsch, Calvin H. ;

Kuller, Lewis H. ;

Cushman, Mary .

CIRCULATION, 2007, 116 (01) :32-38

[6] Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the Assessment of Prognostic Risk Observational Survey [J].

Cuspidi, C ;

Ambrosioni, E ;

Mancia, G ;

Pessina, AC ;

Trimarco, B ;

Zanchetti, A .

JOURNAL OF HYPERTENSION, 2002, 20 (07) :1307-1314

[7] General cardiovascular risk profile for use in primary care - The Framingham Heart Study [J].

D'Agostino, Ralph B. ;

Vasan, Ramachandran S. ;

Pencina, Michael J. ;

Wolf, Philip A. ;

Cobain, Mark ;

Massaro, Joseph M. ;

Kannel, William B. .

CIRCULATION, 2008, 117 (06) :743-753

[8] European guidelines on cardiovascular disease prevention in clinical practice -: Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice [J].

De Backer, G ;

Ambrosioni, E ;

Borch-Johnsen, K ;

Brotons, C ;

Cifkova, R ;

Dallongeville, J ;

Ebrahim, S ;

Faergeman, O ;

Graham, I ;

Mancia, G ;

Cats, VM ;

Orth-Gomér, K ;

Perk, J ;

Pyörälä, K ;

Rodicio, JL ;

Sans, S ;

Sansoy, V ;

Sechtem, U ;

Silber, S ;

Thomsen, T ;

Wood, D .

EUROPEAN HEART JOURNAL, 2003, 24 (17) :1601-1610

[9] Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative [J].

den Ruijter, H. M. ;

Peters, S. A. E. ;

Groenewegen, K. A. ;

Anderson, T. J. ;

Britton, A. R. ;

Dekker, J. M. ;

Engstrom, G. ;

Eijkemans, M. J. ;

Evans, G. W. ;

de Graaf, J. ;

Grobbee, D. E. ;

Hedblad, B. ;

Hofman, A. ;

Holewijn, S. ;

Ikeda, A. ;

Kavousi, M. ;

Kitagawa, K. ;

Kitamura, A. ;

Koffijberg, H. ;

Ikram, M. A. ;

Lonn, E. M. ;

Lorenz, M. W. ;

Mathiesen, E. B. ;

Nijpels, G. ;

Okazaki, S. ;

O'Leary, D. H. ;

Polak, J. F. ;

Price, J. F. ;

Robertson, C. ;

Rembold, C. M. ;

Rosvall, M. ;

Rundek, T. ;

Salonen, J. T. ;

Sitzer, M. ;

Stehouwer, C. D. A. ;

Witteman, J. C. ;

Moons, K. G. ;

Bots, M. L. .

DIABETOLOGIA, 2013, 56 (07) :1494-1502

[10] Long-term health benefits and costs of measurement of carotid intima-media thickness in prevention of coronary heart disease [J].

den Ruijter, Hester M. ;

Vaartjes, Ilonca ;

Sutton-Tyrrell, Kim ;

Bots, Michiel L. ;

Koffijberg, Hendrik .

JOURNAL OF HYPERTENSION, 2013, 31 (04) :782-790

← 1 2 3 4 5 →