Allylcyanation of alkynes: Regio- and stereoselective access to functionalized di- or trisubstituted acrylonitriles

被引：118

作者：

Nakao, Yoshiaki ^{[1
]}

Yukawa, Tomoya ^{[1
]}

Hirata, Yasuhiro ^{[1
]}

Oda, Shinichi ^{[1
]}

Satoh, Jun ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 22期

关键词：

D O I：

10.1021/ja060519g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Allyl cyanides are found to add across alkynes in the presence of a nickel catalyst prepared from Ni(cod)2 and P(4-CF3-C6H4)3 in situ to give variously functionalized di- or trisubstituted acrylonitriles in highly stereoselective manners possibly via a π-allylnickel species as an intermediate. α-Siloxyallyl cyanides also react at the γ-position of a cyano group with both internal and terminal alkynes having various functional groups to give silyl enol ethers, which give the corresponding aldehydes or ketones upon hydrolysis. Copyright © 2006 American Chemical Society.

引用

页码：7116 / 7117

页数：2

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