3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

被引：38

作者：

Abu, Nadiah ^{[1
,2
]}

Akhtar, M. Nadeem ^{[3
]}

Ho, Wan Yong ^{[4
]}

Yeap, Swee Keong ^{[5
]}

Alitheen, Noorjahan Banu ^{[1
]}

机构：

[1] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Serdang 43400, Malaysia

[2] Univ Malaya, Bright Sparks Unit, Kuala Lumpur 53500, Malaysia

[3] Univ Malaysia Pahang, Fac Ind Sci & Technol, Lebuhraya Tun Razak 26300, Kuantan Pahang, Malaysia

[4] Univ Nottingham Malaysia Campus, Semenyih 43500, Selangor Darul, Malaysia

[5] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Malaysia

来源：

MOLECULES | 2013年 / 18卷 / 09期

关键词：

anthraquinone; BHAQ; cytotoxic; MDA-MB231; MCF-7; migration; CYCLE; CYTOTOXICITY; METASTASIS; APOPTOSIS; TARGETS; ASSAY;

D O I：

10.3390/molecules180910367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.

引用

页码：10367 / 10377

页数：11

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