Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer

被引：205

作者：

Smith, MR ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA

来源：

UROLOGY | 2004年 / 63卷 / 04期

关键词：

D O I：

10.1016/j.urology.2003.10.063

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives. To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer. Methods. In a multicenter study, men with Stage MO prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonaclotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months. Results. Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7% 3.0% (P < 0.001). Weight increased by 1.8% +/- 0.5% (P < 0.001). The percentage fat mass increased by 11.0% +/- 1.7%, and the percentage lean mass decreased by 3.8% +/- 0.6% (P < 0.001 for each comparison). Conclusions. Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer. (C) 2004 Elsevier Inc.

引用

页码：742 / 745

页数：4

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