Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8

ATP-Binding cassette subfamily G (ABCG) sterol transporters maintain whole body endogenous and exogenous sterol homeostasis. A substantial portion of exogenous sterols are undigestible phytosterols (plant sterols), which can introduce complications when accumulated. ABCG5/G8 is the main pro-tein functioning to remove ingested plant sterols provid-ing protection from their toxic effects, although, the struc-tural features behind substrate binding in ABCG5/G8 remain poorly resolved. Within this data article, we present ex-tended preceding in the determination of the cholesterol -bound crystal structure and the sterol docking analysis. The crystal structure was deposited in the Protein Data Bank with the accession number of 8CUB, whereas the diffraction im-ages were deposited at the SBGrid Data Bank. This dataset follows the research article entitled as "Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8" (doi: 10.1016/j.jmb.2022.167795).(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )