Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors

被引：13

作者：

Aotsuka, T

Abe, N

Fukushima, K

Ashizawa, N

Yoshida, M

机构：

[1] Research and Development Division, GRELAN Pharmaceutical Co., Ltd., Tokyo, 3-4-3, Sakae-cho, Hamura

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00287-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The benzothiazol-2-ylcarboxylic acids, with diverse spacers between the carboxy group and the benzothiazole ring, were synthesized and evaluated for their ability to inhibit aldose reductase (AR). The phenylacetic acids 6 which have a less complex structure than that of existing AR inhibitors were found to be highly potent, orally active AR inhibitors. (C) 1997 Elsevier Science Ltd.

引用

页码：1677 / 1682

页数：6

共 16 条

[1]

AOTSUKA T, 1994, CHEM PHARM BULL, V42, P1264

[2] Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats [J].