Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance

被引:258
作者
Ting, Darren Shu Jeng [1 ,2 ]
Ho, Charlotte Shan [2 ]
Deshmukh, Rashmi [2 ]
Said, Dalia G. [1 ,2 ]
Dua, Harminder S. [1 ,2 ]
机构
[1] Univ Nottingham, Acad Ophthalmol, Sch Med, Div Clin Neurosci, Nottingham, England
[2] Queens Med Ctr, Dept Ophthalmol, Nottingham, England
基金
英国医学研究理事会;
关键词
COLLAGEN CROSS-LINKING; HERPETIC EYE DISEASE; MICROBIAL KERATITIS; BACTERIAL KERATITIS; FUNGAL KERATITIS; CORNEAL ULCERATION; ACANTHAMOEBA-KERATITIS; OCULAR SURFACE; CLINICAL-FEATURES; 12-YEAR ANALYSIS;
D O I
10.1038/s41433-020-01339-3
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting similar to 6 million of the world population. In addition, it is responsible for 1.5-2.0 million new cases of monocular blindness per year, highlighting an ongoing uncurbed burden on human health. Among all aetiologies such as infection, trauma, inflammation, degeneration and nutritional deficiency, infectious keratitis (IK) represents the leading cause of corneal blindness in both developed and developing countries, with an estimated incidence ranging from 2.5 to 799 per 100,000 population-year. IK can be caused by a wide range of microorganisms, including bacteria, fungi, virus, parasites and polymicrobial infection. Subject to the geographical and temporal variations, bacteria and fungi have been shown to be the most common causative microorganisms for corneal infection. Although viral and Acanthamoeba keratitis are less common, they represent important causes for corneal blindness in the developed countries. Contact lens wear, trauma, ocular surface diseases, lid diseases, and post-ocular surgery have been shown to be the major risk factors for IK. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though its effectiveness is being challenged by the emergence of antimicrobial resistance, including multidrug resistance, in some parts of the world. In this review, we aim to provide an updated review on IK, encompassing the epidemiology, causative microorganisms, major risk factors and the impact of antimicrobial resistance.
引用
收藏
页码:1084 / 1101
页数:18
相关论文
共 159 条
[1]   Bacterial isolates in microbial keratitis: Three-year trend analysis from North India [J].
Acharya, Manisha ;
Farooqui, Javed Hussain ;
Singh, Aastha ;
Gandhi, Arpan ;
Mathur, Umang .
INDIAN JOURNAL OF OPHTHALMOLOGY, 2019, 67 (09) :1508-1509
[2]   Corneal nerves in health and disease [J].
Al-Aqaba, Mouhamed A. ;
Dhillon, Virinder K. ;
Mohammed, Imran ;
Said, Dalia G. ;
Dua, Harminder S. .
PROGRESS IN RETINAL AND EYE RESEARCH, 2019, 73
[3]  
Al-Ghafri Alyaqdhan, 2018, Oman J Ophthalmol, V11, P213, DOI 10.4103/ojo.OJO_4_2018
[4]   The impact of microbial keratitis on quality of life in Uganda [J].
Arunga, Simon ;
Wiafe, Geoffrey ;
Habtamu, Esmael ;
Onyango, John ;
Gichuhi, Stephen ;
Leck, Astrid ;
Macleod, David ;
Hu, Victor ;
Burton, Matthew .
BMJ OPEN OPHTHALMOLOGY, 2019, 4 (01)
[5]   Trends in Antibiotic Resistance Among Ocular Microorganisms in the United States From 2009 to 2018 [J].
Asbell, Penny A. ;
Sanfilippo, Christine M. ;
Sahm, Daniel F. ;
DeCory, Heleen H. .
JAMA OPHTHALMOLOGY, 2020, 138 (05) :439-450
[6]  
Barua Kabita, 2017, J Family Med Prim Care, V6, P345, DOI 10.4103/2249-4863.220030
[7]   Coagulase-Negative Staphylococci [J].
Becker, Karsten ;
Heilmann, Christine ;
Peters, Georg .
CLINICAL MICROBIOLOGY REVIEWS, 2014, 27 (04) :870-926
[8]  
Blomquist Preston Howard, 2006, Trans Am Ophthalmol Soc, V104, P322
[9]   TFOS DEWS II pathophysiology report [J].
Bron, Anthony J. ;
de Paiva, Cintia S. ;
Chauhan, Sunil K. ;
Bonini, Stefano ;
Gabison, Eric E. ;
Jain, Sandeep ;
Knop, Erich ;
Markoulli, Maria ;
Ogawa, Yoko ;
Perez, Victor ;
Uchino, Yuichi ;
Yokoi, Norihiko ;
Zoukhri, Driss ;
Sullivan, David A. .
OCULAR SURFACE, 2017, 15 (03) :438-510
[10]   Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011 [J].
Brown, Allison C. ;
Ross, Jonathan ;
Jones, Daniel B. ;
Collier, Sarah A. ;
Ayers, Tracy L. ;
Hoekstra, Robert M. ;
Backensen, Bryon ;
Roy, Sharon L. ;
Beach, Michael J. ;
Yoder, Jonathan S. ;
Dziewulski, David M. ;
Soyemi, Kenneth ;
Joslin, Charlotte E. ;
Tu, Elmer ;
Samper, Monika ;
Mathers, William ;
Shah, Rupa .
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, 2018, 44 :S173-S178