APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds

被引：15

作者：

Lyall, Donald M. ^{[1
,2
,3
,4
,5
]}

Maniega, Susana Munoz ^{[1
,2
,6
]}

Harris, Sarah E. ^{[1
,4
,5
]}

Bastin, Mark E. ^{[1
,2
,6
]}

Murray, Catherine ^{[1
]}

Lutz, Michael W. ^{[7
]}

Saunders, Ann M. ^{[7
]}

Roses, Allen D. ^{[7
,8
]}

Hernandez, Maria del C. Valdes ^{[1
,2
,6
]}

Royle, Natalie A. ^{[1
,2
,6
]}

Starr, John M. ^{[1
,9
]}

Porteous, David J. ^{[1
,4
,5
]}

Deary, Ian J. ^{[1
,3
]}

Wardlaw, Joanna M. ^{[1
,2
,6
]}

机构：

[1] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Div Neuroimaging Sci, Brain Res Imaging Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Univ Edinburgh, Dept Psychol, Edinburgh EH4 2XU, Midlothian, Scotland

[4] Univ Edinburgh, Med Genet Sect, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland

[5] Western Gen Hosp, MRC Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

[6] Univ Edinburgh, Scottish Imaging Network, Dept Neuroimaging Sci, Edinburgh EH4 2XU, Midlothian, Scotland

[7] Duke Univ, Med Ctr, Dept Neurol, Joseph & Kathleen Bryan Alzheimers Dis Res Ctr, Durham, NC USA

[8] Zinfandel Pharmaceut Inc, Durham, NC USA

[9] Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland

来源：

INTERNATIONAL JOURNAL OF STROKE | 2015年 / 10卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

brain microbleeds; epidemiology; MRI; neurology; risk factors; vascular events; MINI-MENTAL-STATE; BIRTH COHORT 1936; CARDIOVASCULAR-DISEASE; ALZHEIMERS-DISEASE; RISK-FACTORS; TOMM40; APOE; PREVALENCE; AGE; ASSOCIATIONS;

D O I：

10.1111/ijs.12615

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease. Aim and/or hypothesis To test for independent associations between two Alzheimer's disease-susceptibility gene loci APOE epsilon and the TOMM40 '523' poly-T repeat - and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults. Methods Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE e and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72.70 years (standard deviation = 0.7; range = 71-74). Results No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants. Conclusions Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

引用

页码：1297 / 1300

页数：4

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