Three-Dimensional Microtubular Devices for Lab-on-a-Chip Sensing Applications

被引:38
作者
Wang, Jiawei [1 ,3 ,4 ]
Karnaushenko, Daniil [1 ]
Medina-Sanchez, Mariana [1 ]
Yin, Yin [2 ]
Ma, Libo [1 ]
Schmidt, Oliver G. [1 ,3 ,4 ]
机构
[1] IFW Dresden, Inst Integrat Nanosci, D-01069 Dresden, Germany
[2] Jiangsu Univ, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
[3] Tech Univ Chemnitz, Mat Syst Nanoelect, D-09107 Chemnitz, Germany
[4] Tech Univ Chemnitz, Res Ctr Mat Architectures & Integrat Nanomembrane, Rosenbergstr 6, D-09126 Chemnitz, Germany
关键词
sensor; tubular structure; lab-on-a-chip; microcapillary; rolled-up nanotech; whispering gallery mode; curved surface; label-free; magnetoelectronics; WHISPERING-GALLERY MODES; SINGLE NANOPARTICLE DETECTION; MICRO-BUBBLE RESONATOR; MICROBUBBLE RESONATORS; OPTOFLUIDIC SENSOR; RING RESONATORS; WAVE-GUIDES; NANOMEMBRANES; FABRICATION; BIOSENSORS;
D O I
10.1021/acssensors.9b00681
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The rapid advance of micro-/nanofabrication technologies opens up new opportunities for miniaturized sensing devices based on novel three-dimensional (3D) architectures. Notably, microtubular geometry exhibits natural advantages for sensing applications due to its unique properties including the hollow sensing channel, high surface-volume ratio, well-controlled shape parameters and compatibility to on-chip integration. Here the state-of-the-art sensing techniques based on microtubular devices are reviewed. The developed microtubular sensors cover microcapillaries, rolled-up nanomembranes, chemically synthesized tubular arrays, and photoresist-based tubular structures via 3D printing. Various types of microtubular sensors working in optical, electrical, and magnetic principles exhibit an extremely broad scope of sensing targets including liquids, biomolecules, micrometer-sized/nanosized objects, and gases. More-over, they have also been applied for the detection of mechanical, acoustic, and magnetic fields as well as fluorescence signals in labeling-based analyses. At last, a comprehensive outlook of future research on microtubular sensors is discussed on pushing the detection limit, extending the functionality, and taking a step forward to a compact and integrable core module in a lab-on-a-chip analytical system for understanding fundamental biological events or performing accurate point-of-care diagnostics.
引用
收藏
页码:1476 / 1496
页数:41
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