Biodegradable containers composed of anionic liposomes and cationic polypeptide vesicles

被引：16

作者：

Yaroslavov, A. A. ^{[1
]}

Zaborova, O. V. ^{[1
]}

Sybachin, A. V. ^{[1
]}

Kalashnikova, I. V. ^{[1
]}

Kesselman, E. ^{[2
]}

Schmidt, J. ^{[2
]}

Talmon, Y. ^{[2
]}

Rodriguez, A. R. ^{[3
]}

Deming, T. J. ^{[3
,4
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[2] Technion Israel Inst Technol, Dept Chem Engn, IL-32000 Haifa, Israel

[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

RSC ADVANCES | 2015年 / 5卷 / 119期

基金：

俄罗斯科学基金会;

关键词：

DRUG-DELIVERY; PERMEABILITY; COMPLEXES;

D O I：

10.1039/c5ra15863j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electrostatic complexation of liposomes, composed of anionic palmitoyloleoyl phosphatidylserine (POPS1-) and zwitterionic dioleoylphophatidylcholine (DOPC), with bilayer vesicles composed of cationic poly(L-lysine)-b-poly(L-leucine) block copolypeptides has been investigated. The complexation was characterized by several physicochemical methods with the following main conclusions: (a) all added liposomes are totally adsorbed on the polypeptide vesicles up to a certain saturation concentration. (b) The calculated number of liposomes per a single polypeptide vesicle is about 60. (c) The liposomes remain intact (i.e., do not leak) after being complexed with the vesicles. (d) Complexes are stable in physiological ionic strength solution with [NaCl] - 0.15M. (e) The vesicles are effectively digested by proteolytic enzyme trypsin even when covered by liposomes. These findings as well as the high potential for loading of anionic liposomes and cationic vesicles with biologically active compounds make these multi-liposomal complexes promising in the drug delivery field.

引用

页码：98687 / 98691

页数：5

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